There is considerable risk of physical harm when combining these substances. Use extreme caution.
Note: There is a significant risk of seizures. Both substances are CNS depressants, potentiating each other strongly and unpredictably, raising the chances of memory loss, severe ataxia, and unconsciousness. The interaction will cause greater inhibition and risk of injury. If the user falls unconscious it is strongly recommended to put them into the recovery position and monitor breathing. Medical dosages are not reported to be a concern.
Substances in these categories
Pregabalin
Tramadol
Sources
- Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.” — Altair. (n.d.-a)
- Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18. — Ben-Menachem, E. (2004)
- Tramadol induced seizure: A 3-year study. Caspian Journal of Internal Medicine, 3(3), 484–487. — Boostani, R., & Derakhshan, S. (2012)
- Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.” — Douke, R. (n.d.)
- Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597. — French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
- Tramadol: Understanding the Risk of Serotonin Syndrome and Seizures. The American Journal of Medicine, 131(11), 1382.e1-1382.e6. — Hassamal, S., Miotto, K., Dale, W., & Danovitch, I. (2018)
- Risk to heroin users of polydrug use of pregabalin or gabapentin: Risks in combining gabapentoids with heroin. Addiction, 112(9), 1580–1589. — Lyndon, A., Audrey, S., Wells, C., Burnell, E. S., Ingle, S., Hill, R., Hickman, M., & Henderson, G. (2017)
- Pregabalin poisoning: Evaluation of dose‐toxicity relationship. British Journal of Clinical Pharmacology, 88(3), 1288–1297. — Rietjens, S. J., Sikma, M. A., Hunault, C. C., De Lange, D. W., & Hondebrink, L. (2022)
- Pregabalin - Erowid Exp - “Stay Away.” — Sean. (n.d.-b)
- Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20. — Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
Interaction Matrix
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These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.
Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.
One substance may reduce or counteract some of the effects of the other.
These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.
There is considerable risk of physical harm when combining these substances. Use extreme caution.
These combinations are considered dangerous and should be avoided.
The interactions between these substances are not well documented.