These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.
Note: This combination of stimulants will increase strain on the heart, may cause some physical discomfort, and has the chance to cause cardiovascular issues. The anxiogenic and focusing effects of stimulants can increase the chance of unpleasant thought loops and make the experience more uncomfortable, this combination raises these chances. Amphetamines will increase the neurotoxic effects of MDMA, in addition to causing further concerns of hyperthermia due to the inherent nature of the combination. It will also raise one's body temperature, also likely making the combination more neurotoxic.
Substances in these categories
Amphetamines
MDMA
Sources
- MDMA, methamphetamine and their combination: possible lessons for party drug users from recent preclinical research — Kelly J. Clemens, Iain S. McGregor, Glenn E. Hunt, Jennifer L. Cornish
- Repeated weekly exposure to MDMA, methamphetamine or their combination: long-term behavioural and neurochemical effects in rats — Kelly J. Clemens, Iain S. McGregor, Glenn E. Hunt, Jennifer L. Cornish
- Brain hyperthermia induced by MDMA (‘ecstasy’): modulation by environmental conditions — P. Leon Brown, Eugene A. Kiyatkin
Interaction Matrix
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These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.
Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.
One substance may reduce or counteract some of the effects of the other.
These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.
There is considerable risk of physical harm when combining these substances. Use extreme caution.
These combinations are considered dangerous and should be avoided.
The interactions between these substances are not well documented.