These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.
Note: Pregabalin and ketamine may synergize and increase each other's negative side effects such as nausea, dizziness, and loss of consciousness. Caution is advised for beyond medical dosages due to seizure concerns, and medical dosages for individuals with higher risk seizure profiles and or behavior.
Substances in these categories
Ketamine
Pregabalin
Sources
- Prolonged Perioperative Use of Pregabalin and Ketamine to Prevent Persistent Pain after Cardiac Surgery. Anesthesiology, 131(1), 119–131. — Anwar, S., Cooper, J., Rahman, J., Sharma, C., & Langford, R. (2019)
- A Translational Study of the Effects of Ketamine and Pregabalin on Temporal Summation of Experimental Pain. Regional Anesthesia & Pain Medicine, 36(6), 585–591. — Arendt-Nielsen, L., Mansikka, H., Staahl, C., Rees, H., Tan, K., Smart, T. S., Monhemius, R., Suzuki, R., & Drewes, A. M. (2011)
- Unexpected consequences: A case of ketamine‑induced seizure in procedural sedation. Turkish Journal of Emergency Medicine, 24(4), 259–261. — Az, A., & Doğan, Y. (2024)
- Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5(8), a022863. — Barker-Haliski, M., & White, H. S. (2015)
- Pregabalin Pharmacology and Its Relevance to Clinical Practice. Epilepsia, 45(s6), 13–18. — Ben‐Menachem, E. (2004)
- Pregabalin monotherapy in patients with partial-onset seizures: A historical-controlled trial. Neurology, 82(7), 590–597. — French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
- Aggravation of epilepsy by anti‐epileptic drugs. Developmental Medicine & Child Neurology, 48(5), 394–398. — Gayatri, N., & Livingston, J. (2006)
- Drugs that lower the seizure threshold. Adverse Drug Reaction Bulletin, 298(1), 1151–1154. — Hitchings, A. W. (2016)
- Pregabalin poisoning and rising recreational use: a retrospective observational series. British Journal of Clinical Pharmacology, 86(12), 2435–2440. — Isoardi, K. Z., Polkinghorne, G., Harris, K., & Isbister, G. K. (2020)
- Ketamine-induced generalized convulsive seizure during procedural sedation. Archives of Craniofacial Surgery, 22(2), 119–121. — Kim, J. H., Lee, C. K., Yu, S. H., Min, B. D., Chung, C. E., & Kim, D. C. (2021)
- Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. Journal of Neurochemistry, 113(2), 552–561. — Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., & Coderre, T. J. (2010)
- The analgesic efficiency of combined pregabalin and ketamine for total hip arthroplasty: a randomised, double‐blind, controlled study. Anaesthesia, 69(1), 46–52. — Martinez, V., Cymerman, A., Ben Ammar, S., Fiaud, J. F., Rapon, C., Poindessous, F., Judet, T., Chauvin, M., Bouhassira, D., Sessler, D., Mazoit, X., & Fletcher, D. (2014)
- Ketamine: Pro or antiepileptic agent? A systematic review. Heliyon, 10(2), e24433. — Shehata, I. M., Kohaf, N. A., ElSayed, M. W., Latifi, K., Aboutaleb, A. M., & Kaye, A. D. (2024)
- Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20. — Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
- Effect of esketamine combined with pregabalin on acute postsurgical pain in patients who underwent resection of spinal neoplasms: a randomized controlled trial. Pain, 165(9), e96–e105. — Zhou, Y., Sun, W., Fu, Y., Wang, J., Fan, J., Liang, Y., Jia, W., & Han, R. (2024)
Interaction Matrix
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These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.
Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.
One substance may reduce or counteract some of the effects of the other.
These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.
There is considerable risk of physical harm when combining these substances. Use extreme caution.
These combinations are considered dangerous and should be avoided.
The interactions between these substances are not well documented.