These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.
Note: The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops, in addition to the possible negative side effects of coming down from said stimulant while on a psychedelic. In extreme cases, stimulants, especially in combination can result in severe vasoconstriction, tachycardia, hypertension, and heart failure.
Substances in these categories
LSD
Mephedrone
Sources
- 4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse — Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein
- The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue — Michael H Baumann, Mario A Ayestas Jr, John S Partilla, Jacqueline R Sink, Alexander T Shulgin, Paul F Daley, Simon D Brandt, Richard B Rothman, Arnold E Ruoho, Nicholas V Cozzi
- Mephedrone (4-methylmethcathinone) and d-methamphetamine improve visuospatial associative memory, but not spatial working memory, in rhesus macaques — MJ Wright, Jr, SA Vandewater, D Angrish, 2 TJ Dickerson, and MA Taffe
- Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats — J Kehr, F Ichinose, S Yoshitake, M Goiny,1, T Sievertsson, F Nyberg, and T Yoshitake
- Stimulant mechanisms of cathinones - effects of mephedrone and other cathinones on basal and electrically evoked dopamine efflux in rat accumbens brain slices — Jolanta Opacka-Juffry, Thomas Pinnell, Nisha Patel, Melissa Bevan, Meghan Meintel, Colin Davidson
- Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects — Schmid Y, Enzler F, Gasser P, Grouzmann E, Preller KH, Vollenweider FX, Brenneisen R, Müller F, Borgwardt S, Liechti ME
- Distinct acute effects of LSD, MDMA, and D-amphetamine in healthy subjects — Holze F, Vizeli P, Müller F, Ley L, Duerig R, Varghese N, Eckert A, Borgwardt S, Liechti ME
- The vascular effects of trace amines and amphetamines — Kenneth J Broadley
- Cardiovascular and temperature adverse actions of stimulants — James R. Docherty, Hadeel A. Alsufyani
- Pharmacology of Drugs Used as Stimulants — James R. Docherty DSc, Hadeel A. Alsufyani MB, PhD
- Management of New Onset Amphetamine-Induced Acute Decompensated Heart Failure in a Young Adult: Case Report — Breier Y, Azrak E, Banks W, Kushmakov R, Aleshinskaya I
Interaction Matrix
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These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.
Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.
One substance may reduce or counteract some of the effects of the other.
These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.
There is considerable risk of physical harm when combining these substances. Use extreme caution.
These combinations are considered dangerous and should be avoided.
The interactions between these substances are not well documented.