These combinations are considered dangerous and should be avoided.
Note: The two substances potentiate each other strongly and unpredictably, and may rapidly lead to unconsciousness. They both increase each other's side effects such as ataxia, sedation, and CNS depression. Blackout and memory loss risk is significantly increased. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. There is an increased risk of seizures from this combination.
Substances in these categories
GHB/GBL
Pregabalin
Sources
- γ-Hydroxybutyric acid-induced psychosis and seizures. — Cagnin, A., Pompanin, S., Manfioli, V., Briani, C., Zambon, A., Saladini, M., & Dam, M. (2011)
- Selective γ‐hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but fail to activate G protein and to produce the sedative/hypnotic effect of γ‐hydroxybutyric acid. — Castelli, M. P., Ferraro, L., Mocci, I., Carta, F., Carai, M. A. M., Antonelli, T., Tanganelli, S., Cignarella, G., & Gessa, G. L. (2003)
- Postoperative Respiratory Depression Associated with Pregabalin: A Case Series and a Preoperative Decision Algorithm. — Eipe, N., & Penning, J. (2011)
- Determining the Toxicological Significance of Pregabalin in Fatalities. — Elliott, S. P., Burke, T., & Smith, C. (2017)
- Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update. — Evoy, K. E., Sadrameli, S., Contreras, J., Covvey, J. R., Peckham, A. M., & Morrison, M. D. (2021)
- Gamma-hydroxybutyrate: an emerging drug of abuse that causes physical dependence. — Galloway, G. P., Frederick, S. L., Staggers, F. E., Gonzales, M., Stalcup, S. A., & Smith, D. E. (1997)
- Gamma-Hydroxybutyrate Toxicity. In StatPearls. — Le, J. K., & Richards, J. R. (2025a)
- Gamma-Hydroxybutyrate Toxicity. In StatPearls. — Le, J. K., & Richards, J. R. (2025b)
- Seizures as an Adverse Effect of Pregabalin Consumption: A Systematic Review. — Oskouei, Z., Moshiri, M., Raouf-Rahmati, A., Nemati, A., Bemani Naeini, M., Jomehpour, H., Roohbakhsh, A., Salmasi, Z., & Etemad, L. (2025)
- A Critical Evaluation of the Gamma‐Hydroxybutyrate (GHB) Model of Absence Seizures. — Venzi, M., Di Giovanni, G., & Crunelli, V. (2014)
- Various seizure activities following gamma-hydroxybutyrate. — Winters, W. D., & Spooner, C. E. (1965)
Interaction Matrix
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These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.
Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.
One substance may reduce or counteract some of the effects of the other.
These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.
There is considerable risk of physical harm when combining these substances. Use extreme caution.
These combinations are considered dangerous and should be avoided.
The interactions between these substances are not well documented.