Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.
Note: Lithium may be neuroprotective when taken with amphetamines and lithium may decrease the hyperactive and euphoric effects of amphetamines. Lithium may also decrease some negative side effects of amphetamines. Studies indicate this combination is safe.
Substances in these categories
Amphetamines
Lithium
Sources
- Lithium attenuates methamphetamine-induced hyperlocomotion and behavioral sensitization via modulation of prefrontal monoamine release. (2012) — Ago, Y., Tanaka, T., Kita, Y., Tokumoto, H., Takuma, K., & Matsuda, T.
- Strain Differences in Lithium Attenuation of d-Amphetamine-Induced Hyperlocomotion: A Mouse Model for the Genetics of Clinical Response to Lithium. (2007) — Gould, T. D., O’Donnell, K. C., Picchini, A. M., & Manji, H. K.
- Lithium attenuates the activation-euphoria but not the psychosis induced by d-amphetamine in schizophrenia. (1985) — van Kammen, D. P., Docherty, J. P., Marder, S. R., Rosenblatt, J. E., & Bunney, W. E..
- Chronic treatment with mood stabilizer lithium inhibits amphetamine-induced risk-taking manic-like behaviors. (2015) — Zhou, Z., Wang, Y., Tan, H., Bharti, V., Che, Y., & Wang, J.-F.
- Lithium does not attenuate the effects of d-amphetamine in healthy volunteers. (1998) — Silverstone, P. H., Pukhovsky, A., & Rotzinger, S.
Interaction Matrix
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These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.
Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.
One substance may reduce or counteract some of the effects of the other.
These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.
There is considerable risk of physical harm when combining these substances. Use extreme caution.
These combinations are considered dangerous and should be avoided.
The interactions between these substances are not well documented.