These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.
Note: Both substances primarily exert their effects through NMDA antagonism. Currently, there is no evidence regarding mechanisms that might reduce these effects.
Substances in these categories
Dextromethorphan
Ketamine
Sources
- Dextromethorphan — Jeanna M. Marraffa
- Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings) — Georges Mion, Thierry Villevieille
- Four years' treatment with ketamine and a trial of dextromethorphan in a patient with severe post-herpetic neuralgia — P. Klepstad, P. C. Borchgrevink
- Mechanism of action of dextromethorphan/quinidine: comparison with ketamine — Stephen M. Stahl
- Assessment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy male volunteers — A M Hughes,1 J Rhodes,1 G Fisher,2 M Sellers,3 and J W Growcott1
- Effect of Ketamine, Dextromethorphan, and MK-801 on Cochlear Dysfunction Induced by Transient Ischemia — Keiji Tabuchi, MD, Zenya Ito, MD, Shigeki Tsuji, MD, Akira Hara, MD, Tetsuro Wada, MD, Jun Kusakari, MD
Interaction Matrix
Tap or hover on any cell to see the interaction. Click to view details.
These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.
Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.
One substance may reduce or counteract some of the effects of the other.
These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.
There is considerable risk of physical harm when combining these substances. Use extreme caution.
These combinations are considered dangerous and should be avoided.
The interactions between these substances are not well documented.