These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.
Note: High doses of caffeine can potentially exacerbate anxiety, especially during a dissociative experience, due to its stimulating effects. This combination might also lead to physical discomfort. However, individual responses to caffeine can vary significantly, often influenced by factors like habitual versus occasional usage.
Substances in these categories
Caffeine
Dextromethorphan
Sources
- High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens — Chad J Reissig, Lawrence P Carter, Matthew W Johnson, Miriam Z Mintzer, Margaret A Klinedinst, Roland R Griffiths
- The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis — Arthur Eumann Mesas, Luz M Leon-Muñoz, Fernando Rodriguez-Artalejo, Esther Lopez-Garcia
- Coffee, caffeine and blood pressure: a critical review — M-L Nurminen, L Niittynen, R Korpela & H Vapaatalo
Interaction Matrix
Tap or hover on any cell to see the interaction. Click to view details.
These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.
Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.
One substance may reduce or counteract some of the effects of the other.
These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.
There is considerable risk of physical harm when combining these substances. Use extreme caution.
These combinations are considered dangerous and should be avoided.
The interactions between these substances are not well documented.