There is considerable risk of physical harm when combining these substances. Use extreme caution.
Note: There is a significant risk of seizures from this combination. Amphetamines increase respiration rate allowing for a higher dose of sedatives than normal. If amphetamines wears off first, recreational dosages of pregabalin may overcome the individual and cause respiratory arrest. Both substances at recreational dosages cause strain of the heart and may lead to further dangerous heart complications. Medical dosages are not reported to be a concern
Substances in these categories
MDMA
Pregabalin
Sources
- Rave gone wrong: MDMA- induced medical emergency at electrical daisy carnival. A case report. Toxicology Reports, 13, 101739. — Alo, C., & Kioka, M. J. (2024)
- Pregabalin (Lyrica) - Erowid Exp - “Heart Arrhythmia, Seizure : Not Recreational.” — Altair. (n.d.-a)
- Pregabalin pharmacology and its relevance to clinical practice. Epilepsia, 45 Suppl 6, 13–18. — Ben-Menachem, E. (2004)
- MDMA-assisted therapy is associated with a reduction in chronic pain among people with post-traumatic stress disorder. Frontiers in Psychiatry, 13. — Christie, D., Yazar-Klosinski, B., Nosova, E., Kryskow, P., Siu, W., Lessor, D., & Argento, E. (2022)
- Pregabalin & Tramadol - Erowid Exp - “Grand Mal Seizures.” — Douke, R. (n.d.)
- Pregabalin monotherapy in patients with partial-onset seizures. Neurology, 82(7), 590–597. — French, J., Kwan, P., Fakhoury, T., Pitman, V., DuBrava, S., Knapp, L., & Yurkewicz, L. (2014)
- Seizures as an Adverse Effect of Pregabalin Consumption: A Systematic Review. Addiction & Health, 17, 1527. — Oskouei, Z., Moshiri, M., Raouf-Rahmati, A., Nemati, A., Bemani Naeini, M., Jomehpour, H., Roohbakhsh, A., Salmasi, Z., & Etemad, L. (2025)
- Pregabalin poisoning: Evaluation of dose‐toxicity relationship. British Journal of Clinical Pharmacology, 88(3), 1288–1297. — Rietjens, S. J., Sikma, M. A., Hunault, C. C., De Lange, D. W., & Hondebrink, L. (2022)
- Pregabalin - Erowid Exp - “Stay Away.” — Sean. (n.d.-b)
- Pregabalin and paradoxical reaction of seizures in a large overdose. Toxicology Communications, 2(1), 19–20. — Slocum, G. W., Schult, R. F., Gorodetsky, R. M., Wiegand, T. J., Kamali, M., & Acquisto, N. M. (2018)
- Psychological and cardiovascular effects and short-term sequelae of MDMA (“ecstasy”) in MDMA-naïve healthy volunteers. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 19(4), 241–251. — Vollenweider, F. X., Gamma, A., Liechti, M., & Huber, T. (1998)
Interaction Matrix
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These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.
Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.
One substance may reduce or counteract some of the effects of the other.
These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.
There is considerable risk of physical harm when combining these substances. Use extreme caution.
These combinations are considered dangerous and should be avoided.
The interactions between these substances are not well documented.