There is considerable risk of physical harm when combining these substances. Use extreme caution.
Note: Cocaine can decrease some of the intoxicating effects of alcohol, causing some people to drink more than they otherwise would, which leads to greater behavioral and physical health risks. There is also some debate about cocaethylene, a metabolite produced when combining alcohol and cocaine, with some researchers positing that it is more cardiotoxic than cocaine on its own. Use moderation when combining these substances.
Substances in these categories
Alcohol
Cocaine
Sources
- Concurrent use of cocaine and alcohol is more potent and potentially more toxic than use of either alone—A multiple-dose study. — McCance-Katz, E. F., Kosten, T. R., & Jatlow, P.
- Cocaethylene: When cocaine and alcohol are taken together. (2022) — Pergolizzi, J., Breve, F., Magnusson, P., LeQuang, J. A. K., & Varrassi, G.
- Cocaethylene cardiotoxicity in emergency department patients with acute drug overdose. — Shastry, S., Manoochehri, O., Richardson, L. D., & Manini, A. F.
- Patients with detectable cocaethylene are more likely to require intensive care unit admission after trauma. — Wiener, S. E., Sutijono, D., Moon, C. H., Subramanian, R. A., Calaycay, J., Rushbrook, J. I., & Zehtabchi, S.
Interaction Matrix
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These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.
Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.
One substance may reduce or counteract some of the effects of the other.
These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.
There is considerable risk of physical harm when combining these substances. Use extreme caution.
These combinations are considered dangerous and should be avoided.
The interactions between these substances are not well documented.