Dextromethorphan + Mephedrone: Dangerous

Dextromethorphan+Mephedrone

Dangerous

These combinations are considered dangerous and should be avoided.

Note: Risk of serotonin syndrome as both drugs raise serotonin levels. In addition to concerns of high blood pressure and unnecessary strain on the heart. As well as potentially causing anxiety and greater physical discomfort due to the combination.

Substances in these categories

Dextromethorphan

Mephedrone

Sources

Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats — J Kehr, F Ichinose, S Yoshitake, M Goiny, T Sievertsson, F Nyberg, T Yoshitake
4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse — Gregory C. Hadlock, Katy M. Webb, Lisa M. McFadden, Pei Wen Chu, Jonathan D. Ellis, Scott C. Allen, David M. Andrenyak, Paula L. Vieira-Brock, Christopher L. German, Kevin M. Conrad, Amanda J. Hoonakker, James W. Gibb, Diana G. Wilkins, Glen R. Hanson and Annette E. Fleckenstein
Dextromethorphan-induced serotonin syndrome — Anna R. Schwartz, Anthony F. Pizon & Daniel E. Brooks
Dextromethorphan — DrugBank
Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats — Henderson MG, Fuller RW
High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens — Reissig CJ, Carter LP, Johnson MW, Mintzer MZ, Klinedinst MA, Griffiths RR
Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat — Meng H, Cao J, Kang J, Ying X, Ji J, Reynolds W, Rampe D.

Interaction Matrix

Tap or hover on any cell to see the interaction. Click to view details.

✓+Synergy

✓Low Risk

↓Decrease

!Caution

⚠Unsafe

☠Dangerous


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↓	↓	↓	☠	↓	↓		↓	↓	↓	!	⚠	↓	↓	☠	!	?	↓	✓+	↓	?	↓	↓	!	↓	↓	☠	⚠	?	✓	☠
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⚠	!	⚠	⚠	!	☠	↓	!	!		⚠	!	!	⚠	!	!	↓	!	☠	!	?	!	!	!	⚠	✓+	☠	⚠	⚠	✓	☠
⚠	✓+	⚠	☠	⚠	☠	!	!	✓+	⚠		⚠	✓+	⚠	☠	✓+	☠	✓+	☠	☠	☠	✓+	✓+	⚠	⚠	✓+	☠	☠	⚠	☠	☠
?	?	?	☠	!	?	⚠	!	?	!	⚠		!	!	☠	☠	!	!	⚠	?	☠	!	!	☠	!	?	⚠	?	⚠	☠	☠
✓+	✓+	✓+	↓	!	✓+	↓	✓	!	!	✓+	!		✓+	↓	✓+	☠	✓+	✓+	✓+	✓+	✓+	✓+	✓+	✓+	✓+	✓	✓+	✓+	↓	⚠
!	!	!	↓	⚠	☠	↓	!	!	⚠	⚠	!	✓+		↓	✓+	☠	✓+	!	!	!	!	✓+	!	!	✓+	✓	⚠	!	↓	⚠
↓	↓	↓	☠	!	↓	☠	✓	✓+	!	☠	☠	↓	↓		☠	?	↓	✓+	!	!	↓	↓	☠	↓	!	☠	☠	☠	✓	☠
✓+	✓+	✓+	☠	!	✓+	!	✓	✓+	!	✓+	☠	✓+	✓+	☠		✓	✓+	!	✓+	?	✓+	✓+	✓+	✓+	✓+	☠	✓+	!	✓	☠
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✓+	✓+	✓+	↓	!	✓+	↓	✓	!	!	✓+	!	✓+	✓+	↓	✓+	☠		↓	✓+	!	✓+	✓+	✓+	✓+	✓+	✓	✓+	!	↓	⚠
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!	✓+	!	!	!	☠	↓	!	✓+	!	☠	?	✓+	!	!	✓+	☠	✓+	☠		☠	✓+	✓+	!	!	✓+	✓	⚠	⚠	↓	☠
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!	!	!	↓	!	☠	↓	✓	!	!	✓+	!	✓+	!	↓	✓+	☠	✓+	!	✓+	?		✓+	✓+	!	✓+	✓	✓+	!	↓	⚠
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⚠	⚠	⚠	☠	☠	☠	☠	✓	✓+	☠	☠	☠	⚠	⚠	☠	☠	☠	⚠	☠	☠	☠	⚠	⚠	☠	⚠	!	☠	☠	⚠	☠

Low Risk & Synergy

These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.

Low Risk & No Synergy

Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.

Low Risk & Decrease

One substance may reduce or counteract some of the effects of the other.

Caution

These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.

Unsafe

There is considerable risk of physical harm when combining these substances. Use extreme caution.

Dangerous

These combinations are considered dangerous and should be avoided.

Unknown

The interactions between these substances are not well documented.