DOx + Mephedrone: Caution

DOx+Mephedrone

Caution

These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.

Note: The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops, in addition to the possible negative side effects of coming down from said stimulant while on a psychedelic. In extreme cases, stimulants, especially in combination can result in severe vasoconstriction, tachycardia, hypertension, and heart failure.

Substances in these categories

DOx

Mephedrone

Sources

2,5-Dimethoxy-4-iodoamphetamine - an overview — ScienceDirect Topics (n.d.)
The pharmacology and toxicology of the synthetic cathinone mephedrone (4‐methylmethcathinone). Drug Testing and Analysis, 3(7–8), 454–463 — Dargan, P. I., Sedefov, R., Gallegos, A., & Wood, D. M. (2011)
Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats: Mephedrone increases both DA and 5-HT in rat brain. British Journal of Pharmacology, 164(8), 1949–1958 — Kehr, J., Ichinose, F., Yoshitake, S., Goiny, M., Sievertsson, T., Nyberg, F., & Yoshitake, T. (2011)
The origin of 2,5‐dimethoxy‐4‐methylamphetamine (DOM, STP). Drug Testing and Analysis, 16(12), 1496–1508 — Trout, K., & Daley, P. F. (2024)

Interaction Matrix

Tap or hover on any cell to see the interaction. Click to view details.

✓+Synergy

✓Low Risk

↓Decrease

!Caution

⚠Unsafe

☠Dangerous


	!	!	↓	⚠	☠	↓	✓	!	⚠	⚠	?	✓+	!	↓	✓+	☠	✓+	!	!	?	!	✓+	!	!	✓+	✓	☠	?	↓	⚠
!		!	↓	!	☠	↓	✓	!	!	✓+	?	✓+	!	↓	✓+	☠	✓+	!	✓+	?	!	✓+	✓+	!	✓+	✓	✓+	✓+	↓	⚠
!	!		↓	⚠	☠	↓	✓	!	⚠	⚠	?	✓+	!	↓	✓+	?	✓+	☠	!	?	!	✓+	✓+	!	✓+	✓	☠	!	↓	⚠
↓	↓	↓		!	!	☠	✓	✓+	⚠	☠	☠	↓	↓	☠	☠	?	↓	⚠	!	?	↓	↓	☠	↓	!	☠	⚠	?	!	☠
⚠	!	⚠	!		☠	↓	!	!	!	⚠	!	!	⚠	!	!	✓	!	☠	!	?	!	!	!	⚠	✓+	!	⚠	⚠	✓	☠
☠	☠	☠	!	☠		↓	!	!	☠	☠	?	✓+	☠	↓	✓+	?	✓+	☠	☠	?	☠	✓+	☠	☠	✓+	✓	☠	?	☠	☠
↓	↓	↓	☠	↓	↓		↓	↓	↓	!	⚠	↓	↓	☠	!	?	↓	✓+	↓	?	↓	↓	!	↓	↓	☠	⚠	?	✓	☠
✓	✓	✓	✓	!	!	↓		✓	!	!	!	✓	!	✓	✓	?	✓	✓	!	!	✓	✓	✓	!	✓	✓	!	⚠	✓	✓
!	!	!	✓+	!	!	↓	✓		!	✓+	?	!	!	✓+	✓+	?	!	✓+	✓+	?	!	!	✓+	!	✓+	✓+	✓+	✓+	✓	✓+
⚠	!	⚠	⚠	!	☠	↓	!	!		⚠	!	!	⚠	!	!	↓	!	☠	!	?	!	!	!	⚠	✓+	☠	⚠	⚠	✓	☠
⚠	✓+	⚠	☠	⚠	☠	!	!	✓+	⚠		⚠	✓+	⚠	☠	✓+	☠	✓+	☠	☠	☠	✓+	✓+	⚠	⚠	✓+	☠	☠	⚠	☠	☠
?	?	?	☠	!	?	⚠	!	?	!	⚠		!	!	☠	☠	!	!	⚠	?	☠	!	!	☠	!	?	⚠	?	⚠	☠	☠
✓+	✓+	✓+	↓	!	✓+	↓	✓	!	!	✓+	!		✓+	↓	✓+	☠	✓+	✓+	✓+	✓+	✓+	✓+	✓+	✓+	✓+	✓	✓+	✓+	↓	⚠
!	!	!	↓	⚠	☠	↓	!	!	⚠	⚠	!	✓+		↓	✓+	☠	✓+	!	!	!	!	✓+	!	!	✓+	✓	⚠	!	↓	⚠
↓	↓	↓	☠	!	↓	☠	✓	✓+	!	☠	☠	↓	↓		☠	?	↓	✓+	!	!	↓	↓	☠	↓	!	☠	☠	☠	✓	☠
✓+	✓+	✓+	☠	!	✓+	!	✓	✓+	!	✓+	☠	✓+	✓+	☠		✓	✓+	!	✓+	?	✓+	✓+	✓+	✓+	✓+	☠	✓+	!	✓	☠
☠	☠	?	?	✓	?	?	?	?	↓	☠	!	☠	☠	?	✓		☠	?	☠	?	☠	☠	☠	☠	✓	?	?	?	✓	☠
✓+	✓+	✓+	↓	!	✓+	↓	✓	!	!	✓+	!	✓+	✓+	↓	✓+	☠		↓	✓+	!	✓+	✓+	✓+	✓+	✓+	✓	✓+	!	↓	⚠
!	!	☠	⚠	☠	☠	✓+	✓	✓+	☠	☠	⚠	✓+	!	✓+	!	?	↓		☠	?	!	✓+	⚠	!	✓	!	☠	?	☠	☠
!	✓+	!	!	!	☠	↓	!	✓+	!	☠	?	✓+	!	!	✓+	☠	✓+	☠		☠	✓+	✓+	!	!	✓+	✓	⚠	⚠	↓	☠
?	?	?	?	?	?	?	!	?	?	☠	☠	✓+	!	!	?	?	!	?	☠		?	✓+	?	?	?	!	?	⚠	?	☠
!	!	!	↓	!	☠	↓	✓	!	!	✓+	!	✓+	!	↓	✓+	☠	✓+	!	✓+	?		✓+	✓+	!	✓+	✓	✓+	!	↓	⚠
✓+	✓+	✓+	↓	!	✓+	↓	✓	!	!	✓+	!	✓+	✓+	↓	✓+	☠	✓+	✓+	✓+	✓+	✓+		✓+	✓+	✓+	✓	✓+	✓+	↓	⚠
!	✓+	✓+	☠	!	☠	!	✓	✓+	!	⚠	☠	✓+	!	☠	✓+	☠	✓+	⚠	!	?	✓+	✓+		!	✓+	☠	!	!	!	☠
!	!	!	↓	⚠	☠	↓	!	!	⚠	⚠	!	✓+	!	↓	✓+	☠	✓+	!	!	?	!	✓+	!		✓+	✓	✓+	☠	↓	⚠
✓+	✓+	✓+	!	✓+	✓+	↓	✓	✓+	✓+	✓+	?	✓+	✓+	!	✓+	✓	✓+	✓	✓+	?	✓+	✓+	✓+	✓+		!	✓+	!	✓	!
✓	✓	✓	☠	!	✓	☠	✓	✓+	☠	☠	⚠	✓	✓	☠	☠	?	✓	!	✓	!	✓	✓	☠	✓	!		!	☠	✓	☠
☠	✓+	☠	⚠	⚠	☠	⚠	!	✓+	⚠	☠	?	✓+	⚠	☠	✓+	?	✓+	☠	⚠	?	✓+	✓+	!	✓+	✓+	!		?	⚠	☠
?	✓+	!	?	⚠	?	?	⚠	✓+	⚠	⚠	⚠	✓+	!	☠	!	?	!	?	⚠	⚠	!	✓+	!	☠	!	☠	?		?	⚠
↓	↓	↓	!	✓	☠	✓	✓	✓	✓	☠	☠	↓	↓	✓	✓	✓	↓	☠	↓	?	↓	↓	!	↓	✓	✓	⚠	?		☠
⚠	⚠	⚠	☠	☠	☠	☠	✓	✓+	☠	☠	☠	⚠	⚠	☠	☠	☠	⚠	☠	☠	☠	⚠	⚠	☠	⚠	!	☠	☠	⚠	☠

Low Risk & Synergy

These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.

Low Risk & No Synergy

Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.

Low Risk & Decrease

One substance may reduce or counteract some of the effects of the other.

Caution

These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.

Unsafe

There is considerable risk of physical harm when combining these substances. Use extreme caution.

Dangerous

These combinations are considered dangerous and should be avoided.

Unknown

The interactions between these substances are not well documented.