These combinations are considered dangerous and should be avoided.
Note: Tramadol and Lithium both increase the risk of seizures and serotonin syndrome.
Substances in these categories
Lithium
Tramadol
Sources
- Myoclonic seizures with lithium — Steven C. Julius, Richard P. Brenner
- Serotonergic Synergism: The Risks and Benefits of Combining the Selective Serotonin Reuptake Inhibitors with Other Serotonergic Drugs — Charles DeBattista, Mehmet Sofuoglu, and Alan F. Schatzberg
- 5-HT1B Receptors: A Novel Target for Lithium: Possible Involvement in Mood Disorders — Massot, O., Rousselle, JC., Fillion, MP. et al.
- Tramadol: Understanding the Risk of Serotonin Syndrome and Seizures — Sameer Hassamal, Karen Miotto, William Dale, Itai Danovitch
- Tramadol induced seizure: A 3-year study. — Boostani R, Derakhshan S.
- Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat — Lagard, C.; Vodovar, D.; Chevillard, L.; Callebert, J.; Caillé, F.; Pottier, G.; Liang, H.; Risède, P.; Tournier, N.; Mégarbane, B.
- Tramadol — Sansone RA, Sansone LA.
Interaction Matrix
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These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.
Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.
One substance may reduce or counteract some of the effects of the other.
These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.
There is considerable risk of physical harm when combining these substances. Use extreme caution.
These combinations are considered dangerous and should be avoided.
The interactions between these substances are not well documented.