These combinations are considered dangerous and should be avoided.
Note: Both substances are CNS depressants, potentiating each other strongly and unpredictably, raising the chances of memory loss, severe ataxia, and unconsciousness. The interaction will cause greater inhibition and risk of injury. If the user falls unconscious it is strongly recommended to put them into the recovery position and monitor breathing.
Substances in these categories
Diphenhydramine
GHB/GBL
Sources
- Antihistamine Effects on the Central Nervous System, Cognitive Performance and Subjective States. — William J Tharion, Donna J. McMenemy, Terry M. Rauch
- Diphenhydramine — Sicari V, Zabbo CP. Diphenhydramine.
- γ-Hydroxybutyrate (GHB) - Effects on Human Performance and Behavior — Couper FJ, Marinetti LJ.
- GHB Pharmacology and Toxicology: Acute Intoxication, Concentrations in Blood and Urine in Forensic Cases and Treatment of the Withdrawal Syndrome — Busardò FP, Jones AW.
Interaction Matrix
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These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.
Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.
One substance may reduce or counteract some of the effects of the other.
These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.
There is considerable risk of physical harm when combining these substances. Use extreme caution.
These combinations are considered dangerous and should be avoided.
The interactions between these substances are not well documented.