Caffeine + Mephedrone: Caution

Caffeine+Mephedrone

Caution

These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.

Note: This combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and great physical discomfort. However, individual responses to caffeine can vary significantly, often influenced by factors like habitual versus occasional usage.

Substances in these categories

Caffeine

Mephedrone

Sources

The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis — Mesas AE, Leon-Muñoz LM, Rodriguez-Artalejo F, Lopez-Garcia E
Coffee, caffeine and blood pressure: a critical review — Nurminen, ML., Niittynen, L., Korpela, R
Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. — Institute of Medicine (US) Committee on Military Nutrition Research.
The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue — Baumann MH, Ayestas MA Jr, Partilla JS, Sink JR, Shulgin AT, Daley PF, Brandt SD, Rothman RB, Ruoho AE, Cozzi NV
Mephedrone (4-methylmethcathinone) and d-methamphetamine improve visuospatial associative memory, but not spatial working memory, in rhesus macaques — Wright MJ Jr, Vandewater SA, Angrish D, Dickerson TJ, Taffe MA
Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats — Kehr J, Ichinose F, Yoshitake S, Goiny M, Sievertsson T, Nyberg F, Yoshitake T

Interaction Matrix

Tap or hover on any cell to see the interaction. Click to view details.

✓+Synergy

✓Low Risk

↓Decrease

!Caution

⚠Unsafe

☠Dangerous


	!	!	↓	⚠	☠	↓	✓	!	⚠	⚠	?	✓+	!	↓	✓+	☠	✓+	!	!	?	!	✓+	!	!	✓+	✓	☠	?	↓	⚠
!		!	↓	!	☠	↓	✓	!	!	✓+	?	✓+	!	↓	✓+	☠	✓+	!	✓+	?	!	✓+	✓+	!	✓+	✓	✓+	✓+	↓	⚠
!	!		↓	⚠	☠	↓	✓	!	⚠	⚠	?	✓+	!	↓	✓+	?	✓+	☠	!	?	!	✓+	✓+	!	✓+	✓	☠	!	↓	⚠
↓	↓	↓		!	!	☠	✓	✓+	⚠	☠	☠	↓	↓	☠	☠	?	↓	⚠	!	?	↓	↓	☠	↓	!	☠	⚠	?	!	☠
⚠	!	⚠	!		☠	↓	!	!	!	⚠	!	!	⚠	!	!	✓	!	☠	!	?	!	!	!	⚠	✓+	!	⚠	⚠	✓	☠
☠	☠	☠	!	☠		↓	!	!	☠	☠	?	✓+	☠	↓	✓+	?	✓+	☠	☠	?	☠	✓+	☠	☠	✓+	✓	☠	?	☠	☠
↓	↓	↓	☠	↓	↓		↓	↓	↓	!	⚠	↓	↓	☠	!	?	↓	✓+	↓	?	↓	↓	!	↓	↓	☠	⚠	?	✓	☠
✓	✓	✓	✓	!	!	↓		✓	!	!	!	✓	!	✓	✓	?	✓	✓	!	!	✓	✓	✓	!	✓	✓	!	⚠	✓	✓
!	!	!	✓+	!	!	↓	✓		!	✓+	?	!	!	✓+	✓+	?	!	✓+	✓+	?	!	!	✓+	!	✓+	✓+	✓+	✓+	✓	✓+
⚠	!	⚠	⚠	!	☠	↓	!	!		⚠	!	!	⚠	!	!	↓	!	☠	!	?	!	!	!	⚠	✓+	☠	⚠	⚠	✓	☠
⚠	✓+	⚠	☠	⚠	☠	!	!	✓+	⚠		⚠	✓+	⚠	☠	✓+	☠	✓+	☠	☠	☠	✓+	✓+	⚠	⚠	✓+	☠	☠	⚠	☠	☠
?	?	?	☠	!	?	⚠	!	?	!	⚠		!	!	☠	☠	!	!	⚠	?	☠	!	!	☠	!	?	⚠	?	⚠	☠	☠
✓+	✓+	✓+	↓	!	✓+	↓	✓	!	!	✓+	!		✓+	↓	✓+	☠	✓+	✓+	✓+	✓+	✓+	✓+	✓+	✓+	✓+	✓	✓+	✓+	↓	⚠
!	!	!	↓	⚠	☠	↓	!	!	⚠	⚠	!	✓+		↓	✓+	☠	✓+	!	!	!	!	✓+	!	!	✓+	✓	⚠	!	↓	⚠
↓	↓	↓	☠	!	↓	☠	✓	✓+	!	☠	☠	↓	↓		☠	?	↓	✓+	!	!	↓	↓	☠	↓	!	☠	☠	☠	✓	☠
✓+	✓+	✓+	☠	!	✓+	!	✓	✓+	!	✓+	☠	✓+	✓+	☠		✓	✓+	!	✓+	?	✓+	✓+	✓+	✓+	✓+	☠	✓+	!	✓	☠
☠	☠	?	?	✓	?	?	?	?	↓	☠	!	☠	☠	?	✓		☠	?	☠	?	☠	☠	☠	☠	✓	?	?	?	✓	☠
✓+	✓+	✓+	↓	!	✓+	↓	✓	!	!	✓+	!	✓+	✓+	↓	✓+	☠		↓	✓+	!	✓+	✓+	✓+	✓+	✓+	✓	✓+	!	↓	⚠
!	!	☠	⚠	☠	☠	✓+	✓	✓+	☠	☠	⚠	✓+	!	✓+	!	?	↓		☠	?	!	✓+	⚠	!	✓	!	☠	?	☠	☠
!	✓+	!	!	!	☠	↓	!	✓+	!	☠	?	✓+	!	!	✓+	☠	✓+	☠		☠	✓+	✓+	!	!	✓+	✓	⚠	⚠	↓	☠
?	?	?	?	?	?	?	!	?	?	☠	☠	✓+	!	!	?	?	!	?	☠		?	✓+	?	?	?	!	?	⚠	?	☠
!	!	!	↓	!	☠	↓	✓	!	!	✓+	!	✓+	!	↓	✓+	☠	✓+	!	✓+	?		✓+	✓+	!	✓+	✓	✓+	!	↓	⚠
✓+	✓+	✓+	↓	!	✓+	↓	✓	!	!	✓+	!	✓+	✓+	↓	✓+	☠	✓+	✓+	✓+	✓+	✓+		✓+	✓+	✓+	✓	✓+	✓+	↓	⚠
!	✓+	✓+	☠	!	☠	!	✓	✓+	!	⚠	☠	✓+	!	☠	✓+	☠	✓+	⚠	!	?	✓+	✓+		!	✓+	☠	!	!	!	☠
!	!	!	↓	⚠	☠	↓	!	!	⚠	⚠	!	✓+	!	↓	✓+	☠	✓+	!	!	?	!	✓+	!		✓+	✓	✓+	☠	↓	⚠
✓+	✓+	✓+	!	✓+	✓+	↓	✓	✓+	✓+	✓+	?	✓+	✓+	!	✓+	✓	✓+	✓	✓+	?	✓+	✓+	✓+	✓+		!	✓+	!	✓	!
✓	✓	✓	☠	!	✓	☠	✓	✓+	☠	☠	⚠	✓	✓	☠	☠	?	✓	!	✓	!	✓	✓	☠	✓	!		!	☠	✓	☠
☠	✓+	☠	⚠	⚠	☠	⚠	!	✓+	⚠	☠	?	✓+	⚠	☠	✓+	?	✓+	☠	⚠	?	✓+	✓+	!	✓+	✓+	!		?	⚠	☠
?	✓+	!	?	⚠	?	?	⚠	✓+	⚠	⚠	⚠	✓+	!	☠	!	?	!	?	⚠	⚠	!	✓+	!	☠	!	☠	?		?	⚠
↓	↓	↓	!	✓	☠	✓	✓	✓	✓	☠	☠	↓	↓	✓	✓	✓	↓	☠	↓	?	↓	↓	!	↓	✓	✓	⚠	?		☠
⚠	⚠	⚠	☠	☠	☠	☠	✓	✓+	☠	☠	☠	⚠	⚠	☠	☠	☠	⚠	☠	☠	☠	⚠	⚠	☠	⚠	!	☠	☠	⚠	☠

Low Risk & Synergy

These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.

Low Risk & No Synergy

Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.

Low Risk & Decrease

One substance may reduce or counteract some of the effects of the other.

Caution

These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.

Unsafe

There is considerable risk of physical harm when combining these substances. Use extreme caution.

Dangerous

These combinations are considered dangerous and should be avoided.

Unknown

The interactions between these substances are not well documented.