These combinations are considered dangerous and should be avoided.
Substances in these categories
Opioids
Pregabalin
Sources
- Gabapentin enhances the analgesic effect of morphine in healthy volunteers. Anesthesia and Analgesia, 91(1), 185–191. — Eckhardt, K., Ammon, S., Hofmann, U., Riebe, A., Gugeler, N., & Mikus, G. (2000)
- Postoperative respiratory depression associated with pregabalin: A case series and a preoperative decision algorithm. Pain Research & Management: The Journal of the Canadian Pain Society, 16(5), 353–356. — Eipe, N., & Penning, J. (2011)
- Determining the Toxicological Significance of Pregabalin in Fatalities. Journal of Forensic Sciences, 62(1), 169–173. — Elliott, S. P., Burke, T., & Smith, C. (2017)
- Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update. Drugs, 81(1), 125–156. — Evoy, K. E., Sadrameli, S., Contreras, J., Covvey, J. R., Peckham, A. M., & Morrison, M. D. (2021)
- Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case–control study. PLOS Medicine, 14(10), e1002396. — Gomes, T., Juurlink, D. N., Antoniou, T., Mamdani, M. M., Paterson, J. M., & Brink, W. van den. (2017)
- Risk to heroin users of polydrug use of pregabalin or gabapentin: Risks in combining gabapentoids with heroin. Addiction, 112(9), 1580–1589. — Lyndon, A., Audrey, S., Wells, C., Burnell, E. S., Ingle, S., Hill, R., Hickman, M., & Henderson, G. (2017)
- Predictors of Gabapentin Overuse With or Without Concomitant Opioids in a Commercially Insured U.S. Population. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 38(4), 436–443. — Peckham, A. M., Evoy, K. E., Covvey, J. R., Ochs, L., Fairman, K. A., & Sclar, D. A. (2018)
- FDA warns about serious breathing problems with seizure and nerve pain medicines gabapentin (Neurontin, Gralise, Horizant) and pregabalin (Lyrica, Lyrica CR). FDA. — Research, C. for D. E. and. (2020)
Interaction Matrix
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These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.
Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.
One substance may reduce or counteract some of the effects of the other.
These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.
There is considerable risk of physical harm when combining these substances. Use extreme caution.
These combinations are considered dangerous and should be avoided.
The interactions between these substances are not well documented.