These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.
Note: Both substances may increase each other's side effects, such as sedation, lowered blood pressure, and raised heart rate.
Substances in these categories
Cannabis
Pregabalin
Sources
- Cannabidiol Interactions with Medications, Illicit Substances, and Alcohol: a Comprehensive Review (2021) — Balachandran, P., Elsohly, M., & Hill, K. P.
- Therapeutic use of cannabis in the US. The Nurse Practitioner, 47(12) (2022) — Klein, T. A., & Clark, C. S.
- Influence of Pregabalin Maintenance on Cannabis Effects and Related Behaviors in Daily Cannabis Users. Experimental and Clinical Psychopharmacology, 30(5) (2022) — Lile, J. A., Alcorn, J. L., Hays, L. R., Kelly, T. H., Stoops, W. W., Wesley, M. J., & Westgate, P. M.
- Potential Pharmacokinetic Drug‐Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain (2020) — Vázquez, M., Guevara, N., Maldonado, C., Guido, P. C., & Schaiquevich, P.
Interaction Matrix
Tap or hover on any cell to see the interaction. Click to view details.
These drugs work together to cause an effect greater than the sum of its parts. They aren't likely to cause an adverse or undesirable reaction when used carefully.
Effects are additive. The combination is unlikely to cause any adverse or undesirable reaction beyond those that might ordinarily be expected from these drugs.
One substance may reduce or counteract some of the effects of the other.
These combinations are not usually physically harmful, but may produce undesirable effects. Use caution.
There is considerable risk of physical harm when combining these substances. Use extreme caution.
These combinations are considered dangerous and should be avoided.
The interactions between these substances are not well documented.